Toll-like receptors in teleosts

نویسندگان

  • Tomokazu Takano
  • TOMOKAZU TAKANO
  • HIDEHIRO KONDO
  • IKUO HIRONO
  • MAKOTO ENDO
  • TATSUO SAITO-TAKI
  • TAKASHI AOKI
چکیده

Toll-like receptors (TLR) recognize the pathogen-associated molecular patterns (PAMPs) and regulate the subsequent immune responses in mammals. We have so far succeeded in finding the 11 types of TLR genes from Japanese flounder (Paralichthys olivaceus). TLR genes have also been found in the genomes of fugu (Takifugu rubripes) and zebrafish (Danio rerio). However, only limited information is known about the function of TLRs in fish. The fragmentary information of the fish TLR gene expression, immune response following PAMPs stimulation and intracellular signaling are available in fish. In addition, the phylogenetic analysis in vertebrate TLR genes and comparison of TLR family members between teleost fish species revealed that specific divergence of TLR genes between mammals and fish as well as between fish species. Here, the possible functions of teleost fish TLR and its importance are discussed.

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تاریخ انتشار 2012